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Markovnikov vs anti-Markovnikov addition

Markovnikov's rule for alkene addition, the carbocation logic behind it, and when peroxides flip the regiochemistry.

Quick answer When HX adds to an unsymmetrical alkene, the H goes to the carbon that already has more H's, and X goes to the more substituted carbon — because that's the path through the more stable carbocation. With HBr + peroxides (radical mechanism), the regiochemistry flips: H ends up on the more substituted carbon instead.

The rule in plain words

Markovnikov's original statement: when HX adds across a double bond, the hydrogen ends up on the carbon that already has more hydrogens. The modern version: the H+ adds to give the most stable carbocation intermediate. Both wordings give the same answer for simple alkenes.

Carbocation logic

H+ adds first, giving one of two possible carbocations. Mark which side of the alkene becomes more substituted — that's where the H went. The more substituted carbocation is more stable (3° > 2° > 1° > methyl), so it forms preferentially. The nucleophilic X then attacks that cation. Net result: the X attached to the more substituted carbon.

Anti-Markovnikov (radical HBr)

When peroxides are added (a radical initiator), HBr adds by a radical chain. Br• adds first to the alkene, giving the more stable radical (3° > 2° > 1°). H then adds to whatever's left. The Br ends up on the LESS substituted carbon — the opposite of the ionic outcome. Memorize: "peroxides flip the bromide."

Other anti-Markovnikov methods

Hydroboration-oxidation (BH₃ then H₂O₂/NaOH) gives an anti-Markovnikov alcohol — the boron goes to the less hindered carbon (sterics), then oxidation puts OH where B was. Oxymercuration-demercuration gives the Markovnikov alcohol cleanly because no rearrangement happens.

Draw this on the whiteboard

Open the OChem Board whiteboard — benzene rings, wedge/dash bonds, and a clickable periodic table built in. No account needed.

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